Key result
Nitric oxide synthase activity in the kidney is regulated by substrate and cofactor availability, protein-protein interactions, phosphorylation, and expression levels.
Design
Review
Authors
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Complex renal NOS regulation may affect BP control; leaves open isoform-specific therapeutic targets.
This review highlights the complex regulatory mechanisms of nitric oxide synthase isoforms in the kidney, which are crucial for renal function and blood pressure control.
Herrera et al. (2005) conducted a review in Nitric oxide regulation in the kidney. Nitric oxide synthase activity in the kidney is regulated by substrate and cofactor availability, protein-protein interactions, phosphorylation, and expression levels.
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