March 1, 2002British Journal of PharmacologyOpen Access

Characterization of an apamin‐sensitive small‐conductance Ca²⁺‐activated K⁺ channel in porcine coronary artery endothelium: relevance to EDHF

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Population

Porcine coronary arteries and freshly-isolated endothelial cells

Design

Preclinical

Authors

MBMatthew BurnhamUniversity of Hawaiʻi at Mānoa RBRostislav BychkovNational Institutes of Health MFMichel FélétouServier (France)

Discussion

Member takes

Implication

Extends preclinical EDHF mechanism data in porcine models; leaves open translation to human coronary endothelial function.

Structured PICO

Population

Porcine coronary arteries and freshly-isolated endothelial cells

Intervention

Substance P, 1-ethyl-2-benzimidazolinone (1-EBIO), charybdotoxin, apamin, and d-tubocurarine

Outcome

Characterization of the apamin-sensitive small-conductance Ca(2+)-activated K(+) channel (SK(Ca)) via electrophysiological recordings, mRNA detection, and protein expressionsurrogate

The study demonstrates that porcine coronary artery endothelium expresses an apamin-sensitive SKCa channel containing the SK3 subunit, which plays a key role in the EDHF response.

Cite This Study

Burnham et al. (2002) studied this question.

synapsesocial.com/papers/6a092ce11d1abd907d1608e2 https://doi.org/10.1038/sj.bjp.0704551

Topics

Thymosin beta-4

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