Key result
Positive beta1-adrenergic receptor autoantibodies predicted sudden cardiac death in patients with dilated (HR 4.51; 95% CI 2.405-8.471) and ischaemic cardiomyopathy (HR 3.749; 95% CI 2.389-5.884).
Why the study?
Does the presence of beta1-adrenergic and M2 muscarinic receptor autoantibodies predict sudden cardiac death in patients with chronic heart failure?
Observational (n=2,886)
Does the presence of beta1-adrenergic and M2 muscarinic receptor autoantibodies predict sudden cardiac death in patients with chronic heart failure?
Effect estimate: HR 4.51 (DCM), HR 3.749 (ICM) (95% CI 2.405-8.471 (DCM), 2.389-5.884 (ICM))
Positive beta1-adrenergic receptor autoantibodies serve as an independent predictor for sudden cardiac death in patients with chronic heart failure.
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May refine SCD risk stratification in HF; leaves open whether testing improves prevention strategies.
Pei et al. (2012) conducted an observational in Chronic Heart Failure (n=2,886). Beta1-adrenergic and M2 muscarinic receptor autoantibodies vs. Control subjects was evaluated on Sudden cardiac death (SCD) (HR 4.51 (DCM), HR 3.749 (ICM), 95% CI 2.405-8.471 (DCM), 2.389-5.884 (ICM)). Positive beta1-adrenergic receptor autoantibodies predicted sudden cardiac death in patients with dilated (HR 4.51; 95% CI 2.405-8.471) and ischaemic cardiomyopathy (HR 3.749; 95% CI 2.389-5.884).
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