Key result
A raised brain natriuretic peptide (BNP) level predicted sudden cardiac death (RR 3.68; 95% CI 1.90-7.14) and ventricular arrhythmias (RR 2.54; 95% CI 1.87-3.44).
Why the study?
Does a raised BNP level predict sudden cardiac death and ventricular arrhythmias in patients with and without ICDs?
Population
14 studies pooling 4,590 patients, including 6 studies of patients without implantable cardioverter…
Comparison
Raised Brain Natriuretic Peptide (BNP) level vs Lower or normal BNP level
Design
Meta-analysis
Authors
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BNP elevation supports SCD/VA risk stratification; extends mortality data yet requires prospective validation of incremental value.
Meta-Analysis (n=4,590)
Does a raised BNP level predict sudden cardiac death and ventricular arrhythmias in patients with and without ICDs?
Effect estimate: RR 3.68 (95% CI 1.90-7.14)
Elevated BNP is a significant predictor of sudden cardiac death and ventricular arrhythmias, though its incremental value over other risk stratification tools requires further prospective study.
Scott et al. (2009) conducted a meta-analysis in Risk of sudden cardiac death and ventricular arrhythmias (n=4,590). Raised Brain Natriuretic Peptide (BNP) vs. Lower/normal BNP was evaluated on Sudden cardiac death (SCD) (RR 3.68, 95% CI 1.90-7.14). A raised brain natriuretic peptide (BNP) level predicted sudden cardiac death (RR 3.68; 95% CI 1.90-7.14) and ventricular arrhythmias (RR 2.54; 95% CI 1.87-3.44).
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