The relationship between serum vitamin D levels and hematological inflammatory indices in patients with heart failure

The relationship between serum vitamin D levels and hematological inflammatory indices in patients with heart failureH eart failure (HF) is a clinical syndrome that occurs as a result of structural and/or functional abnormalities in the heart.It can lead to the impairment of ventricular filling and/ or ejection.Multiple processes, including those involving myocardial damage and ventricular remodeling, are involved in the pathogenesis of HF [1].Inflammation is one of the major pathophysiological contributors to both acute and chronic heart failure (CHF) [1].The activation of neurohormonal systems and hemodynamic overload may trigger myocardial inflammatory responses [1,2].Consequently, inflammatory activation plays an important role in CHF disease progression through my-Objectives: Recent studies have suggested that chronic systemic inflammation increases the risk of development and progression of heart failure (HF).Vitamin D may contribute to the pathogenesis of HF by modulating inflammatory pathways.Changes in brain natriuretic peptide (BNP) levels are critical for the diagnosis and assessment of HF severity.We aimed to investigate the association between serum vitamin D levels, BNP, and novel hematological systemic inflammation indices in chronic heart failure (CHF) patients.Methods: In this retrospective study, we report data from 187 participants admitted to the outpatient clinic, with 85 CHF and 102 without CHF (control group).Vitamin D, BNP, and complete blood cell samples were analyzed.Novel hematological systemic inflammation indices-the systemic immune-inflammation index (SII; neutrophil platelet / lymphocyte), the systemic inflammation response index (SIRI; neutrophil count monocyte/lymphocyte count), the pan-immune-inflammation value (PIV; neutrophil count platelet count monocyte count)/lymphocyte count, monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR)-were calculated.Results: Binomial logistic regression showed that only MLR was significantly associated with CHF (P < 0.001).A weak, negative, and statistically significant correlation was found between BNP and vitamin D (r=-0.185,p=0.011) levels.There was a weak negative correlation between vitamin D and PLR p=0.007), p=0.048), p=0.033).