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November 1, 1975Journal of Biological ChemistryOpen Access

Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.

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Authors

JGJL GoldsteinAmerican Heart AssociationSDS E DanaThe University of Texas Southwestern Medical CenterJFJR FaustThe University of Texas Southwestern Medical Center

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Goldstein et al. (1975) studied this question.

synapsesocial.com/papers/6a092fb4b7dd28a06e1607f7https://doi.org/10.1016/s0021-9258(19)40786-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts1974 · 1,503 citations
  2. 2Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells1975 · 43 citations
  3. 3Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339.1975 · 311 citations
  4. 4Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.1975 · 209 citations
  5. 5Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.1975 · 321 citations