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March 1, 1974Proceedings of the National Academy of SciencesOpen Access

Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

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MBMichael S. BrownHospital of the University of PennsylvaniaJoseph L. GoldsteinJoseph L. GoldsteinThe University of Texas Southwestern Medical Center

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Brown et al. (1974) studied this question.

synapsesocial.com/papers/6a092fb4b7dd28a06e160800https://doi.org/10.1073/pnas.71.3.788
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts1974 · 545 citations
  2. 2Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins1973 · 345 citations
  3. 3PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,705 citations
  4. 4THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM1955 · 8,814 citations
  5. 5Measurements of the molecular-weight variability of plasma low-density lipoproteins among normals and subjects with hyper-β-lipoproteinemia. Demonstration of macromolecular heterogeneity1972 · 117 citations