Key result
Men with left ventricular dysfunction exhibited significantly greater increases in left ventricular mass index (+48% vs +3%) and BNP (+373% vs +48%) compared to women.
Why the study?
Are there gender-specific differences in cardiac remodeling and neurohumoral activation in subjects with left ventricular dysfunction?
Population
1,883 subjects (992 female, 891 male) from two MONICA surveys in Augsburg, Germany.
Comparison
Male gender (observational comparison) vs Female gender
Design
Cross-sectional
Authors
Loading...
May indicate sex-specific remodeling in LV dysfunction warranting monitoring; hypothesis-generating and should not yet change practice.
Observational (n=1,883)
No
Are there gender-specific differences in cardiac remodeling and neurohumoral activation in subjects with left ventricular dysfunction?
Absolute Event Rate: 48% vs 3%
p-value: p=<0.01
Men with left ventricular dysfunction exhibit more pronounced cardiac remodeling and neurohumoral activation compared to women, suggesting gender-specific adaptations to hemodynamic overload.
Andreas Luchner (2002) conducted an observational in Left ventricular dysfunction (n=1,883). Male gender vs. Female gender was evaluated on Increase in left ventricular mass index (LVMI) in subjects with LV dysfunction compared to normal LV function (p=<0.01). Men with left ventricular dysfunction exhibited significantly greater increases in left ventricular mass index (+48% vs +3%) and BNP (+373% vs +48%) compared to women.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: