Early thrombolysis (<1.5 h) and adequate reperfusion (<75% residual stenosis) with streptokinase were associated with smaller infarcts and better ventricular function in acute myocardial infarction.
Cohort (n=30)
Temporal changes in residual stenosis in the infarct-related coronary artery and ventricular function were studied in 30 consecutive patients with an acute myocardial infarction who received rapid, high dose intravenous infusions of streptokinase within 4 h of pain onset. Patients were studied 6 days and 3.9 +/- 1.3 months after the acute episode. Inferior infarction, early thrombolysis (less than 1.5 h after pain onset) and adequate reperfusion (less than 75% residual stenosis in the infarct-related coronary artery) were associated with smaller left ventricular infarcts, smaller ventricular volumes and better ventricular function. Residual stenosis tended to increase with time and in 6 patients the artery closed completely (1 with an overt clinical episode). Ventricular function and volumes improved progressively in patients with good initial function and less residual stenosis in the infarct-related coronary artery.
Lotan et al. (Tue,) conducted a cohort in acute myocardial infarction (n=30). intravenous streptokinase was evaluated on Temporal changes in residual stenosis in the infarct-related coronary artery and ventricular function. Early thrombolysis (<1.5 h) and adequate reperfusion (<75% residual stenosis) with streptokinase were associated with smaller infarcts and better ventricular function in acute myocardial infarction.