Key result
Homozygous familial hypercholesterolemia was associated with significantly elevated total plasma apo E levels (137.6 µg/ml) compared to heterozygous subjects (69.4 µg/ml) and controls (46.5 µg/ml).
Why the study?
How does the plasma lipoprotein distribution of apolipoprotein E differ in subjects with familial hypercholesterolemia compared to controls?
Observational
How does the plasma lipoprotein distribution of apolipoprotein E differ in subjects with familial hypercholesterolemia compared to controls?
Absolute Event Rate: 137.6% vs 46.5%
p-value: p=<0.001
Homozygous familial hypercholesterolemia is associated with significantly elevated total plasma apo E levels and an increased mass of apo E-enriched HDL, potentially reflecting a compensatory mechanism for reverse cholesterol transport in the absence of LDL receptors.
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May indicate compensatory reverse cholesterol transport in homozygous FH; leaves open apo E as a therapeutic target.
Gibson et al. (1987) conducted an observational in Familial hypercholesterolemia (FH). Homozygous familial hypercholesterolemia vs. Heterozygous FH and healthy controls was evaluated on Total plasma apo E levels (p=<0.001). Homozygous familial hypercholesterolemia was associated with significantly elevated total plasma apo E levels (137.6 µg/ml) compared to heterozygous subjects (69.4 µg/ml) and controls (46.5 µg/ml).
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