Why the study?
Are HDL lipid and apoprotein values abnormal in patients with homozygous familial hypercholesterolemia compared to their relatives?
Population
9 homozygotes with familial hypercholesterolemia (FH), along with their heterozygote and unaffected relatives.
Design
Cross-sectional
Authors
Loading...
Homozygous FH patients show HDL abnormalities associated with high atherosclerosis risk; cross-sectional data leave open causality and therapeutic targets.
Are HDL lipid and apoprotein values abnormal in patients with homozygous familial hypercholesterolemia compared to their relatives?
Homozygous familial hypercholesterolemia is associated with marked quantitative and qualitative abnormalities in HDL, which may contribute to their high risk of occlusive atherosclerosis.
Goldberg et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: