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A newly developed assay measuring mitogen-stimulated lymphocyte proliferation in lipoprotein-depleted medium can successfully identify and distinguish individuals who are heterozygous or homozygous for LDL-receptor abnormalities causing familial hypercholesterolemia. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 3, 1986New England Journal of Medicine

Detection of Familial Hypercholesterolemia by Assaying Functional Low-Density-Lipoprotein Receptors on Lymphocytes

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Authors

JCJennifer A. CuthbertThe University of Texas Southwestern Medical Center CECara EastNovartis (United States)DBDavid W. BilheimerMannKind Corporation (United States)

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Cuthbert et al. (1986) studied this question.

synapsesocial.com/papers/6a09301efebbf018f8160257 https://doi.org/10.1056/nejm198604033141404

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April 3, 1986New England Journal of Medicine

Detection of Familial Hypercholesterolemia by Assaying Functional Low-Density-Lipoprotein Receptors on Lymphocytes

View Full Paper

Ask AI

Bookmark

Authors

JCJennifer A. CuthbertThe University of Texas Southwestern Medical Center CECara EastNovartis (United States)DBDavid W. BilheimerMannKind Corporation (United States)

Discussion

Member takes

Implication

Key Points

Key points are not available for this paper at this time.

Cite This Study

Cuthbert et al. (1986) studied this question.

synapsesocial.com/papers/6a09301efebbf018f8160257 https://doi.org/10.1056/nejm198604033141404

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