Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIA
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Key result
Genetic analysis of 2520 relatives of 176 myocardial infarction survivors identified familial combined hyperlipidemia as a new, distinct autosomal dominant disorder.
Population
2520 relatives and spouses of 176 survivors of myocardial infarction
Design
Cross-sectional
Authors
Discussion
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Implication
May inform family lipid screening after MI; leaves open prevalence, mechanisms, and therapies in modern cohorts.
Study Design
Type
Observational (n=2,520)
Multicenter
No
Structured PICO
P
Population
2520 relatives and spouses of 176 survivors of myocardial infarction (149 hyperlipidemic and 27 normolipidemic)
O
Outcome
Distribution of fasting plasma cholesterol and triglyceride values and segregation analyses to identify genetic lipid disorderssurrogate
This classic study delineated familial combined hyperlipidemia as a distinct, common autosomal dominant genetic disorder among survivors of myocardial infarction.
Limitations
- Potential bias in sorting data for heterogeneity based on quantitative variation alone
- Arbitrary 95th percentile cut-off values for distinguishing normolipidemic and hyperlipidemic individuals
Cite This Study
Goldstein et al. (1973) conducted an observational in Hyperlipidemia in Coronary Heart Disease (n=2,520). Genetic analysis of 2520 relatives of 176 myocardial infarction survivors identified familial combined hyperlipidemia as a new, distinct autosomal dominant disorder.
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