Key result
Angiotensin II infusion for 7 days resulted in higher mean systolic blood pressures in old males (172 mm Hg) and young males (161 mm Hg) compared to old females (157 mm Hg) and young females (143 mm Hg).
Why the study?
Does Angiotensin II infusion differentially affect blood pressure and renal sodium transporters based on age and sex in mice?
Does Angiotensin II infusion differentially affect blood pressure and renal sodium transporters based on age and sex in mice?
Increased sensitivity to Angiotensin II in aging and male mice may involve overactivity of the thiazide-sensitive NaCl cotransporter.
BACKGROUND/AIMS: We determined the effects of age and sex on the blood pressure (BP) response to angiotensin II (Ang II) infusion and evaluated the potential mechanistic role of the thiazide-sensitive NaCl cotransporter (NCC) and the epithelial sodium channel (ENaC). METHODS: Male and female mice (approximately 3 or 21 months of age) were infused with Ang II or control for 7 days. RESULTS: Males had a greater BP response to Ang II, somewhat enhanced by aging. Mean systolic BPs (at 7 days) were (mm Hg): 161, 143, 172, and 157 in young male, young female, old male, and old female mice, respectively. Immunoblotting changes in the whole kidney that supported this BP profile included a 51 and 52% increase in NCC band density in the old females and old males (as compared to sex-respective controls) with Ang II infusion, while the young males and young females showed an increase of 40 and 0%, respectively. Young males also had a greater reduction in major bands of beta- and gamma-ENaC, than did young female mice. The natriuretic response to hydrochlorothiazide supported an increase in activity of NCC with Ang II in aged mice only. CONCLUSIONS: Increased sensitivity to Ang II in aging and male mice may involve overactivity of NCC.
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Tiwari et al. (2009) studied Blood pressure response to Angiotensin II. Angiotensin II infusion vs. Control was evaluated on Mean systolic blood pressure at 7 days. Angiotensin II infusion for 7 days resulted in higher mean systolic blood pressures in old males (172 mm Hg) and young males (161 mm Hg) compared to old females (157 mm Hg) and young females (143 mm Hg).
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