A cDNA clone encoding a second type‐2A protein phosphatase catalytic subunit (2A β ) was isolated from a rabbit skeletal muscle cDNA library constructed in λgt10. The deduced protein sequence (309 residues, 35.59 kDa) was 97% identical to that of phosphatase 2A α (309 residues, 35.58 kDa). At the nucleotide level, the two clones showed only 82% identity in the coding region. The results indicate the presence of at least two isoforms of protein phosphatase 2A in skeletal muscle.
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Silva et al. (1987) studied this question.
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