Key result
Serum lipoprotein lipase concentration was lower in men than women (45.5 vs 56.0 µg/L) and correlated positively with HDL-C (r=0.549) and inversely with triglycerides (r=-0.423).
Why the study?
Does serum LPL concentration correlate with lipid parameters in healthy subjects?
Observational (n=240)
Does serum LPL concentration correlate with lipid parameters in healthy subjects?
Serum LPL concentration correlates positively with HDL-C and inversely with triglycerides, suggesting it modulates these lipid levels in normal subjects.
Serum LPL associates with HDL-C and triglycerides in healthy adults; hypothesis-generating and requires prospective studies before clinical adoption.
Using serum samples obtained from normal individuals who had not received heparin injection, we investigated the relationship of lipoprotein lipase (LPL) to lipid and apolipoprotein concentrations in serum. For the measurement of LPL concentration, a highly sensitive enzyme-linked immunosorbent assay (ELISA) was developed, in which the lowest detection limit was 9 micrograms/L. The mean (SD) serum LPL concentration was 50.7 (14.9) micrograms/L (n = 240). It was lower in men [45.5 (14.0) micrograms/L in men and 56.0 (13.9) micrograms/L in women]. Serum LPL concentration correlated positively with high-density lipoprotein cholesterol (HDL-C, r = 0.549) and apolipoprotein AI (apoAI, r = 0.487), and inversely with triglycerides (r = -0.423). Our results suggest that serum LPL may be a factor in the modulation of HDL-C and triglyceride concentrations in normal subjects.
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Saito et al. (1998) conducted an observational in Healthy subjects (n=240). Serum lipoprotein lipase concentration was lower in men than women (45.5 vs 56.0 µg/L) and correlated positively with HDL-C (r=0.549) and inversely with triglycerides (r=-0.423).
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