Key result
Adipose sympathetic innervation regulates metabolism by controlling adipocyte transitions between white and brown states.
Why the study?
While obesity research has advanced in neuronal circuits and adipocyte biology to regulate metabolism, the interface of neuro-adipocyte interaction remains less studied.
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Design
Review
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This review highlights emerging concepts in the neuronal regulation of adipocyte transitions and their role in metabolic regulation.
Obesity research progresses in understanding neuronal circuits and adipocyte biology to regulate metabolism. However, the interface of neuro-adipocyte interaction is less studied. We summarize the current knowledge of adipose tissue innervation and interaction with adipocytes and emphasize adipocyte transitions from white to brown adipocytes and vice versa. We further highlight emerging concepts for the differential neuronal regulation of brown/beige versus white adipocyte and the interdependence of both for metabolic regulation.
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Münzberg et al. (2021) studied this question. Sympathetic innervation of adipose tissue regulates metabolism through the differential neuronal control of adipocyte transitions between white and brown or beige states.
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