Modified technique identifies identical 5' termini coordinates in β-globin mRNA precursor and mature form.
We have used a modification of the Berk-Sharp technique to determine that the 5' termini of the mouse 15 S beta-globin precursor and the mature mRNA have identical map coordinates. The modification involves the use of 5' (or 3') terminally labeled probes; it allows the detection of the precursor in the presence of excess mature mRNA.
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Weaver et al. (1979) studied this question.
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