Key result
Three-dimensional vector data provided a more accurate and stable solution in current source reconstruction compared to normal components data, especially for dipoles with widely changing directions.
Using 3D data in magnetocardiogram source reconstruction provides more accurate and stable localization of heart activation abnormalities in simulation models.
May enhance source localization in magnetocardiography models; leaves open translation to human cardiac mapping.
We present a study of current source reconstruction in MCG using a distributed current source model. We first test the efficiency of the inversion algorithm using a simulation model, selecting a short sequence of dipoles that generate dipolar magnetic fields. After adding noise to the calculated direct fields, the inverse computation is performed and the results are compared to the dipoles of the simulation data. The calculations are repeated with different levels of noise and different values of the regularization parameter, using only the normal components and all three components of the generated fields. The analysis of the magnetic field maps (MFM) sequence may help in identifying abnormalities during the ventricular repolarization. To assess the ability of the source reconstruction in detecting these disturbances, more complex simulation analyses can be performed, using a time series of dipoles that produces a sequence of MFMs as the ones generated by the normal heart activity. After introducing a perturbation in the activation of some dipoles in a specific region of the myocardium, inverse computation is performed to localize the heart activation inhomogeneities. The results show that 3D data allow finding a more accurate and stable solution.
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Melis et al. (2009) studied Simulated human magnetocardiogram. 3D vector components data vs. Normal components data was evaluated on Correlation between simulated and reconstructed dipoles. Three-dimensional vector data provided a more accurate and stable solution in current source reconstruction compared to normal components data, especially for dipoles with widely changing directions.
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