Key result
Overweight status was associated with the lowest all-cause inpatient mortality in systolic and diastolic heart failure, whereas cachexia had the highest mortality (P<0.001).
Why the study?
The obesity paradox has been reported in heart failure, but characterization of this observation specifically in systolic and diastolic heart failure was needed.
Does body mass index category affect all-cause inpatient mortality in patients hospitalized with systolic or diastolic heart failure?
Observational
Does body mass index category affect all-cause inpatient mortality in patients hospitalized with systolic or diastolic heart failure?
p-value: p=< 0.001
This study extends evidence of a partial obesity paradox in heart failure, demonstrating that overweight and obese patients have lower inpatient mortality compared to those with cachexia in both systolic and diastolic heart failure.
Overweight HF inpatients had lower mortality than cachectic; hypothesis-generating for obesity paradox and should not yet change practice.
INTRODUCTION: A phenomenon known as the obesity paradox has been reported in patients with heart failure (HF). The goal of this study is to characterize this observation in systolic (SHF) and diastolic (DHF) HF. METHODS AND RESULTS: < 0.001). CONCLUSIONS: All-cause inpatient mortality in SHF and DHF is lowest in overweight populations followed by obese and morbidly obese populations, whereas cachexia has the highest mortality.
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Movahed et al. (2025) conducted an observational in Systolic and diastolic heart failure. Body mass index categories (overweight, obese, morbidly obese, cachexia) was evaluated on All-cause inpatient mortality (p=< 0.001). Overweight status was associated with the lowest all-cause inpatient mortality in systolic and diastolic heart failure, whereas cachexia had the highest mortality (P<0.001).
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