Key result
A review of the molecular and genetic determinants of cardiac repolarization highlights how pathologic events and environmental stress can modify these factors to cause repolarization abnormalities.
Understanding how environmental stress modifies genetic determinants of cardiac repolarization may yield insights into causes and treatments for repolarization abnormalities.
May prompt consideration of environmental stressors in repolarization assessment; leaves open targeted interventions pending validation.
Although a variety of factors, inherited or environmental, can influence expression of ion channel proteins to impact on repolarization, that environment can affect genetic determinants of repolarization for intervals of varying duration is a concept that is not as generally appreciated as it should be. In the following pages we review the molecular/genetic determinants of cardiac repolarization and summarize how pathologic events and environmental intrusions can affect these determinants. Understanding the chains of events involved should yield insights into both the causes and potential avenues of treatment for abnormalities of repolarization.
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Rosen et al. (2005) conducted a review in Abnormalities of cardiac repolarization. A review of the molecular and genetic determinants of cardiac repolarization highlights how pathologic events and environmental stress can modify these factors to cause repolarization abnormalities.
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