Key result
In Chinese patients with chronic heart failure, metoprolol treatment improved cardiac and motor functions, but women reported significantly higher systolic blood pressure at 12 months compared to men (125.47 vs 122.28 mm Hg).
Why the study?
This study was conducted to assess sex differences in cardiac and motor functions, quality of life, and mental status in Chinese chronic heart failure patients following metoprolol treatment.
Does metoprolol continuous release tablets improve cardiac and motor functions, quality of life, and mental status in Chinese chronic heart failure patients with resting heart rate >80 beats/min?
Observational (n=154)
No
Does metoprolol continuous release tablets improve cardiac and motor functions, quality of life, and mental status in Chinese chronic heart failure patients with resting heart rate >80 beats/min?
Metoprolol improves cardiac and motor functions as well as quality of life in chronic heart failure patients, but may negatively impact mental status with distinct sex differences.
This study assessed sex differences in cardiac and motor functions, quality of life (QoL), and mental status in Chinese chronic heart failure (CHF) patients after metoprolol treatment.This single-center prospective study, conducted from February 2013 to April 2016, included CHF patients (men and women) with resting heart rate (HR) >80 beats/min using metoprolol continuous release tablets. Metoprolol-induced changes in cardiac and motor functions, QoL, and mental status at 1, 3, 6, 9, and 12 months from baseline, within and between the sexes, were analyzed. Descriptive data were represented as counts, percentages, and mean ± standard deviation. Differences at various follow-up periods were compared using repeated measures one-way analysis of variance, followed by post hoc Dunnett's multiple comparison test. Statistical significance was considered at P < .05.Compared with men, women reported significantly higher systolic blood pressure (SBP) (122.28 ± 6.76 vs 125.47 ± 6.67 mm Hg, P < .05) and Veterans Specific Activity Questionnaire score (8.16 ± 0.98 vs 8.47 ± 0.89, P = .05) at 12 months. Men reported higher Hospital Anxiety and Depression Scale scores for depression than women at 1 month (10.27 vs 8.83, P < .05) and for anxiety at 12 months (8.4 vs 7.72, P < .05). Metoprolol significantly decreased HR and Minnesota Living with Heart Failure Questionnaire score in men (64.5 ± 3.13 and 53.7 ± 8.00) and women (65.38 ± 3.32 and 53.85 ± 8.42, respectively). Ejection fraction (%, men: 50.00 ± 4.45, women: 50.72 ± 4.09), cardiac index (L/min/m, men: 2.70 ± 0.25, women: 2.78 ± 0.23), 6-minute walk test distance (m, men: 414.41 ± 20.84, women: 420.34 ± 20.35), and short form-8 questionnaire scores (men: 52.05 ± 1.94, women: 52.19 ± 2.58) increased significantly in both the sexes (P < .001 for all) at 12 months. Copenhagen Burnout Inventory score significantly increased in men (mean score 62.43, P < .05).Metoprolol treatment improves cardiac and motor functions, QoL, and anxiety scores but causes greater depression and burnout in men and women. Sex was seen to affect mental status of CHF patients the most.
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Wu et al. (2019) conducted an observational in Chronic heart failure (n=154). Metoprolol vs. Men (sex-based comparison) was evaluated on Systolic blood pressure at 12 months (p=<0.05). In Chinese patients with chronic heart failure, metoprolol treatment improved cardiac and motor functions, but women reported significantly higher systolic blood pressure at 12 months compared to men (125.47 vs 122.28 mm Hg).
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