Key result
Enoximone resulted in a smaller decrease in myocardial oxygen consumption for a given decrease in stress-time integral compared to nitroprusside (slope 0.51 vs 1.27, p<0.05).
Why the study?
Does enoximone compared to nitroprusside alter myocardial oxygen consumption relative to hemodynamic changes in patients with dilated cardiomyopathy?
Does enoximone compared to nitroprusside alter myocardial oxygen consumption relative to hemodynamic changes in patients with dilated cardiomyopathy?
Absolute Event Rate: 0.51% vs 1.27%
p-value: p=<0.05
The inotropic effect of enoximone partially counteracts the energy-saving benefits of its vasodilatory effect in patients with dilated cardiomyopathy.
No takes yet. Share an insight, caveat, or question.
May limit net energetic benefit of vasodilation in dilated cardiomyopathy; leaves open whether enoximone affects outcomes versus nitroprusside.
Hasenfuß et al. (1989) studied Idiopathic dilated cardiomyopathy (n=22). Enoximone vs. Nitroprusside was evaluated on Slope of linear regression between decrease in myocardial oxygen consumption and decrease in systolic stress-time integral (p=<0.05). Enoximone resulted in a smaller decrease in myocardial oxygen consumption for a given decrease in stress-time integral compared to nitroprusside (slope 0.51 vs 1.27, p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: