Key result
Aggressive BP reduction may increase cardiovascular events, but current evidence remains inconclusive.
Why the study?
Does aggressive reduction of blood pressure increase cardiovascular events (the J-curve phenomenon) in certain populations?
Does aggressive reduction of blood pressure increase cardiovascular events (the J-curve phenomenon) in certain populations?
The existence of a J-shaped curve for cardiovascular mortality with aggressive blood pressure reduction remains controversial and requires further prospective study.
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Urges caution with intensive BP lowering in vulnerable patients; leaves open J-curve confirmation in prospective trials.
Robles et al. (2018) conducted a review in Hypertension. Aggressive reduction of blood pressure was evaluated on Cardiovascular events and mortality. Aggressive reduction of blood pressure may increase cardiovascular events (the J-curve phenomenon), though current evidence from observational and prospective trials remains inconclusive.
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