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May 17, 2026Urology Research and PracticeOpen Access

Multicenter Study on Integrating Prostate Magnetic Resonance Imaging with Prostate-Specific Antigen Density for Risk-Adapted Biopsy Strategy in a South Korean Cohort

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Authors

SLSeung-ju LeeSt. Vincent's HospitalDSDong Ho ShinSeoul St. Mary's HospitalHKHee Youn KimSt. Vincent's Hospital

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Implication

Randomized trial evaluates csPCa detection in South Korean cohort, suggesting improved biopsy strategies.

Key Points

  • This study aims to assess the effectiveness of combining PI-RADS and PSAD for detecting clinically significant prostate cancer while minimizing unnecessary biopsies.
  • Multicenter retrospective study of 3117 biopsy-naïve patients from two hospitals in South Korea (2020-2025).
  • Patients were stratified into PI-RADS groups and PSAD categories for analysis.
  • Receiver-operating characteristic (ROC) curve analyses were conducted to identify optimal PSAD cut-offs.
  • Overall csPCa detection rate was 47.1%.
  • PI-RADS 4-5 patients had detection rates between 20.1%-76.5% across all PSAD levels.
  • Optimal PSAD cut-offs determined were 0.155 for PI-RADS 1-2 and 0.145 for PI-RADS 3, achieving a negative predictive value of 93.8%.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6a095a427880e6d24efe0586https://doi.org/10.5152/tud.2026.26014
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Precision in prostate cancer detection: integrating prostate-specific antigen density (PSAD) and the Prostate Imaging Reporting and Data System (PI-RADS) to provide additional risk stratification for a more accurate diagnostic decision2024 · 10 citations
  2. 2Combining Multiparametric Magnetic Resonance Imaging and Prostate-Specific Antigen Density in Selecting Patients for Prostate Biopsy2026
  3. 3PI-RADS category and biopsy-confirmed clinically significant prostate cancer in a selected Ecuadorian multiparametric MRI cohort: a cross-sectional diagnostic study2026
  4. 4Avoiding unnecessary biopsy in suspicious prostate cancer using PRIMARY score ≤3 and PSAD ≤0.2 ng/mL/cm3: a real-world, dual-center study from China2026 · 3 citations
  5. 5Integration of PSAd and multiparametric MRI to forecast biopsy outcomes in biopsy-naïve patients with PSA 4~20 ng/ml2024 · 3 citations