Epiretinal Membrane Is Associated With Acquired Vitelliform Lesion Morphometrics in Intermediate Age-Related Macular Degeneration

Purpose: To investigate the impact of epiretinal membrane (ERM) on the structural characteristics of acquired vitelliform lesions (AVLs) in eyes with intermediate age-related macular degeneration (AMD).Design: cross-sectional study.Participants: Eyes of patients with intermediate AMD-associated AVLs were identified from a tertiary referral center database.significance (811.1 251.0 m vs 676.8 416.0 m; p = 0.057).The prevalence of IHRF, EZ disruption, ELM disruption, and AVL location over drusen did not differ significantly between groups.Effect size analysis demonstrated a moderate positive effect for apical AVL height (Hedges' g 0.65; 95% CI ~0.15 to 1.10), whereas AVL width showed a small-tomoderate effect size with confidence intervals crossing zero. Conclusions:In eyes with AMD-associated AVLs, the presence of ERM is associated with increased AVL height without corresponding differences in other outer retinal structural features.These findings suggest that vitreomacular traction may selectively influence AVL configuration.Longitudinal studies are needed to determine whether traction-related modulation of AVL morphology impacts AMD disease progression and AVL collapse.