Immuno-PET/CT Imaging of Trop2 Expression with [ ¹⁸ F]AlF-RESCA-RT4 Enhances Diagnosis of Breast Cancers and the Metastases

Wenzhi Jia; Tingting Yan; Shuxian An; You Zhang; Qianyun Wu; Ziping Wu; Dongsheng Xu; Zhoumi Hu; Cheng Wang; Gang Huang; Jianjun Liu; Yanping Lin; Weijun Wei

doi:10.2967/jnumed.125.271093

May 14, 2026Journal of Nuclear Medicine

Immuno-PET/CT Imaging of Trop2 Expression with [ ¹⁸ F]AlF-RESCA-RT4 Enhances Diagnosis of Breast Cancers and the Metastases

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Key Points

The aim is to evaluate Trop2 expression across different molecular subtypes of breast cancer and assess the efficacy of a new imaging tracer.
Evaluated Trop2 expression using a novel tracer, [<sup>18</sup>F]AlF-RESCA-RT4.
Performed imaging across various molecular subtypes of breast cancer.
Compared diagnostic performance against standard imaging techniques.
Trop2 expression was higher in aggressive subtypes, indicating a potential diagnostic marker.
The novel tracer provided enhanced imaging clarity compared to traditional methods.
Significant improvement in diagnosis of metastases was observed, enhancing treatment planning.

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Implication

Evaluates Trop2 expression diagnostics in breast cancers, suggesting improved imaging methods.

Abstract

This study aimed to evaluate human trophoblast cell surface antigen 2 (Trop2) expression across molecular subtypes of breast cancer and assess the diagnostic performance of a novel Trop2-targeted tracer, [

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Jia et al. (2026) studied this question.

synapsesocial.com/papers/6a095a877880e6d24efe07a4 https://doi.org/10.2967/jnumed.125.271093

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Immuno-PET/CT Imaging of Trop2 Expression with [ ¹⁸ F]AlF-RESCA-RT4 Enhances Diagnosis of Breast Cancers and the Metastases

Key Points

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Implication

Abstract

Discussion

Cite This Study

Immuno-PET/CT Imaging of Trop2 Expression with [ ¹⁸ F]AlF-RESCA-RT4 Enhances Diagnosis of Breast Cancers and the Metastases

Key Points

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Implication

Abstract

Discussion

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