What question did this study set out to answer?

This review aims to consolidate neuroimaging evidence regarding the effects of recreational cannabis use on brain integrity.

What Do Thirty Years of Neuroimaging Research Tell Us About Recreational Cannabis Use and Brain Integrity? A Narrative Review of the Multimodal Neuroimaging Evidence to Date

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Narrative review summarizes multimodal neuroimaging findings linking cannabis use and brain integrity, highlighting implications for brain health.

This review aims to consolidate neuroimaging evidence regarding the effects of recreational cannabis use on brain integrity.
Narrative review of multimodal neuroimaging studies on cannabis use.
Summarized findings from both acute intoxication studies and observational studies of regular users.
Utilized different neuroimaging tools including PET, fMRI, and sMRI.
Acute THC intoxication linked to increased activity in fronto-striatal pathways.
Regular cannabis users showed lower hippocampal volume (p<0.05) and altered white matter integrity in the superior longitudinal fasciculus.
Evidence of altered neurochemistry in cannabis users, including lower N-acetyl aspartate and glucose metabolism in the frontal cortex.

Murphy et al. (2026) studied this question.

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Narrative review summarizes multimodal neuroimaging findings linking cannabis use and brain integrity, highlighting implications for brain health.