Association of serum levels of zinc and copper with pathophysiological features of polycystic ovary syndrome

Trace elements may play a role as initiating environmental factors in polycystic ovary syndrome (PCOS). This study was designed to assess the relationship between circulating levels of zinc (Zn) and copper (Cu) and the pathophysiological features of PCOS. A cross-sectional study was conducted. Clinical data were recorded and blood samples were taken to analyze biochemical and hormonal parameters. The subgroup of participants defined with abnormal background had body mass excess, insulin resistance, or subclinical inflammation. In PCOS patients with insulin resistance, elevated Cu, Zn, and Cu/Zn ratio levels were observed. However, the Zn/Cu ratio was lower in those with body mass excess and subclinical inflammation. Significant correlations within PCOS patient subgroups, linking trace elements to anthropometric, metabolic, inflammatory, and hormonal variables, were revealed. Interactions of trace elements in PCOS pathophysiology are likely complex. Hence, supplementation, if considered, should be approached cautiously.