What question did this study set out to answer?

This study aims to evaluate the cytotoxic and cytogenetic effects of graphene oxide and zinc oxide nanocomposites on human cell models.

May 17, 2026Black Sea Journal of Engineering and ScienceOpen Access

From Synthesis to Cellular Response: Physicochemical Characterization and in Vitro Toxicological Evaluations of Graphene Oxide- and ZnO-Based Nanocomposites

View Full Paper

Ask AI

Bookmark

This study aims to evaluate the cytotoxic and cytogenetic effects of graphene oxide and zinc oxide nanocomposites on human cell models.
Synthesized and characterized various nanomaterials including ZnO/GO and ZnO/rGO.
Conducted cytotoxicity assessments through MTT assay in DLD-1 and CCD-18Co cell lines.
Evaluated mitotic index in human peripheral lymphocytes after exposure to nanomaterials.
No significant cytotoxic effects were observed at concentrations from 0.25-1200 µg/mL for 24 hours.
A concentration-dependent decrease in mitotic index was noted after 24- and 48-hour treatment with 10-150 µg/mL.
Potential cytogenetic effects were indicated, warranting further research on long-term exposure.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Randomized trial evaluates cytotoxic and cytogenetic responses of ZnO and graphene oxide nanocomposites in human cells, indicating potential safety concerns.

Cite This Study

Akbaş et al. (2026) studied this question.

synapsesocial.com/papers/6a095b5d7880e6d24efe1195 https://doi.org/10.34248/bsengineering.1858302

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial evaluates cytotoxic and cytogenetic responses of ZnO and graphene oxide nanocomposites in human cells, indicating potential safety concerns.

From Synthesis to Cellular Response: Physicochemical Characterization and in Vitro Toxicological Evaluations of Graphene Oxide- and ZnO-Based Nanocomposites

Key Points

Discussion

Implication

Cite This Study

From Synthesis to Cellular Response: Physicochemical Characterization and in Vitro Toxicological Evaluations of Graphene Oxide- and ZnO-Based Nanocomposites

Key Points

Discussion

Implication

Cite This Study