Development of coumarin-sulfonate scaffolds for cholinesterase inhibition: experimental and computational studies toward Alzheimer's disease therapy

Ehsan Ullah Mughal; Nafeesa Naeem; Aneela Shaheen Cheema; Gehan Ahmed Othman; Amina Sadiq; Songül Bayrak; Namık Kılınç; Mohammed B. Hawsawi; Sobhi M. Gomha; Züleyha Almaz

doi:10.1039/d6ra02535h

January 1, 2026RSC AdvancesOpen Access

Development of coumarin-sulfonate scaffolds for cholinesterase inhibition: experimental and computational studies toward Alzheimer's disease therapy

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Key Points

The aim is to develop and evaluate coumarin-based sulfonate esters as cholinesterase inhibitors for Alzheimer’s disease.
Synthesized coumarin sulfonate esters from 4-methyl-7-hydroxycoumarin.
Characterized the compounds using IR and NMR techniques.
Measured AChE and BChE inhibition potency in vitro.
All compounds exhibited low-nanomolar IC50 values for AChE inhibition.
All compounds exhibited low-nanomolar IC50 values for BChE inhibition.

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Implication

Experimental and computational studies demonstrate strong enzyme inhibition in Alzheimer’s disease therapies.

Abstract

Coumarin-based sulfonate esters (1–9) were synthesized from 4-methyl-7-hydroxycoumarin and characterized by IR/NMR. All compounds showed strong AChE and BChE inhibition with low-nanomolar IC 50 values.

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Cite This Study

Mughal et al. (2026) studied this question.

synapsesocial.com/papers/6a095b5d7880e6d24efe1234 https://doi.org/10.1039/d6ra02535h

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Development of coumarin-sulfonate scaffolds for cholinesterase inhibition: experimental and computational studies toward Alzheimer's disease therapy

Key Points

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Implication

Abstract

Discussion

Cite This Study

Development of coumarin-sulfonate scaffolds for cholinesterase inhibition: experimental and computational studies toward Alzheimer's disease therapy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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