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May 17, 2026Molecular Nutrition & Food Research

Modulation of Microbiota‐Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation

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Authors

PJPaige E. JamiesonIGInah GuNRNicholas J. Reichart

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Overview

Randomized trial shows symptom improvement in Crohn's disease with xanthohumol, suggesting beneficial gut modulation.

Key Points

  • To explore the effects of xanthohumol on the gut environment and symptoms in individuals with Crohn's disease.
  • Randomized, placebo-controlled trial (NCT4590508)
  • 19 participants with clinically active Crohn's disease
  • Xanthohumol 24 mg/day or placebo for 8 weeks with clinical assessments bi-weekly.
  • Significant reduction in secondary bile acids in XN-treated individuals
  • Increased IL-10 levels correlated with improved Crohn's disease activity index (CDAI) scores
  • CDAI scores improved in participants receiving xanthohumol.

Cite This Study

Jamieson et al. (2026) studied this question.

synapsesocial.com/papers/6a095ba67880e6d24efe1733https://doi.org/10.1002/mnfr.70501
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Also Consider

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  4. 4Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor2020 · 122 citations
  5. 5Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet‐Induced Obese Mice2021 · 30 citations