Palladium-catalyzed cycloaddition generates spirooxindole derivatives from hydroxy-tethered carbonates, suggesting broader applications.
A palladium-catalyzed [4 + 2] cycloaddition of isatin-derived hydroxy-tethered allylic carbonates with 1,1-dicyanoalkenes has been developed to afford various spirooxindole-tetrahydropyran derivatives in moderate to high yields with excellent diastereoselectivities. The scale-up reaction and further derivations of the product also worked well. The current reaction demonstrated that isatin-derived hydroxy-tethered allylic carbonates are viable precursors for palladium-catalyzed cycloaddition reactions and are expected to find broader applications.
No takes yet. Share an insight, caveat, or question.
Gu et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: