Access to spiro-isoxazoline via a palladium-catalyzed carboetheri-fication of cycloalkenyl-tethered oximes

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This is a Experimental Study study.

Qicai Ma; Yuanyuan Li; Zhi‐Ping Liu; Chengming Wang; Wei Zhou

doi:10.1039/d5qo01162k

January 1, 2025Organic Chemistry Frontiers

Access to spiro-isoxazoline via a palladium-catalyzed carboetheri-fication of cycloalkenyl-tethered oximes

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Key Points

The method efficiently synthesizes spiro-isoxazolines using a palladium-catalyzed process.
Utilizing cycloalkenyl-tethered oximes with aryl and alkenyl bromides creates diverse compounds.
This tandem approach enables a wide range of possible product variations.
The protocol highlights a novel strategy within palladium-catalyzed synthetic methodologies.

Implication

This research demonstrates an efficient palladium-catalyzed carboetherification method using cycloalkenyl-tethered oximes and aryl bromides.

Abstract

This study presents an efficient method for synthesizing spiro-isoxazolines through a tandem palladium-catalyzed carboetherification approach. Utilizing cycloalkenyl-tethered oximes and aryl/alkenyl bromides, this protocol enables the construction of a wide range...

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Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68d6cd5bb1249cec298b32e3 https://doi.org/10.1039/d5qo01162k

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Access to spiro-isoxazoline via a palladium-catalyzed carboetheri-fication of cycloalkenyl-tethered oximes

Key Points

Implication

Abstract

Discussion

Cite This Study

Access to spiro-isoxazoline via a palladium-catalyzed carboetheri-fication of cycloalkenyl-tethered oximes

Key Points

Implication

Abstract

Discussion

Cite This Study

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