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May 17, 2026Current Reviews in Clinical and Experimental Pharmacology

Role of Lysosomal Genes for Parkinson's Pathogenesis: Insights from Molecular Mechanism to Therapeutic Strategies

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Authors

VBVidhan Chand BalaAGAsheesh Kumar GuptaAKAmit Kumar

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Overview

This review clarifies the role of lysosomal genes in Parkinson’s Disease, highlighting therapeutic strategies and implications.

Key Points

  • The review clarifies the role of lysosomal genes in Parkinson’s Disease and their molecular mechanisms.
  • Reviewed contributions of lysosomal genes like GBA1, LRRK2, and PRKN to pathology.
  • Investigated lysosomal enzyme dysfunction and its effect on α-synuclein accumulation.
  • Explored various therapeutic strategies targeting lysosomal dysfunction.
  • Lysosomal dysfunction significantly contributes to α-synuclein accumulation in Parkinson's Disease.
  • Combinatorial treatment strategies show potential to enhance therapeutic efficacy despite existing limitations.
  • Targeting lysosomal pathways represents a promising approach for improving Parkinson's Disease treatment.

Cite This Study

Bala et al. (2026) studied this question.

synapsesocial.com/papers/6a095c147880e6d24efe2097https://doi.org/10.2174/0127724328441801260406095625
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