A Streamlined Lithiation-Cyclization Strategy Unlocks Broad-Scope, Efficient Access to Chiral 3,4-Dihydroisoquinolones and Isoindolinones

Wenjun Luo; Hehua Lin; Ruinan Zhang; Genwei Zhang; 唐少斌; Daohong Yu; Zhengwang Chen; Zhong-Xia Wang; Junliang Zhang

doi:10.1039/d6qo00462h

January 1, 2026Organic Chemistry Frontiers

A Streamlined Lithiation-Cyclization Strategy Unlocks Broad-Scope, Efficient Access to Chiral 3,4-Dihydroisoquinolones and Isoindolinones

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Key Points

The aim is to create a simplified approach for synthesizing chiral 3,4-dihydroisoquinolones and isoindolinones.
Developed a lithiation-cyclization method to streamline production.
Enabled rapid and scalable access to chiral compounds.
Successfully synthesized diverse chiral 3,4-dihydroisoquinolones and isoindolinones.
Demonstrated high efficiency and broad substrate scope in the synthesis process.

Implication

Develops a streamlined strategy for efficient access to chiral compounds, suggesting enhanced synthesis methods.

Abstract

Chiral 3,4-dihydroisoquinolones and isoindolinones serve as important chiral building blocks in pharmaceutical and natural product synthesis. Herein, we have developed a simplified and straightforward strategy that enables rapid and scalable...

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Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/6a095c147880e6d24efe20ba https://doi.org/10.1039/d6qo00462h

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A Streamlined Lithiation-Cyclization Strategy Unlocks Broad-Scope, Efficient Access to Chiral 3,4-Dihydroisoquinolones and Isoindolinones

Key Points

Implication

Abstract

Discussion

Cite This Study

A Streamlined Lithiation-Cyclization Strategy Unlocks Broad-Scope, Efficient Access to Chiral 3,4-Dihydroisoquinolones and Isoindolinones

Key Points

Implication

Abstract

Discussion

Cite This Study

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