What does this research mean for the field?

While systemic lupus erythematosus is observationally associated with an elevated risk of coronary artery disease, Mendelian randomization reveals no genetic evidence for a direct causal relationship between the two. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research investigates the potential causal relationship between systemic lupus erythematosus (SLE) and coronary artery disease (CAD) using meta-analysis and Mendelian randomization.

May 17, 2026MedicineOpen Access

Causal relationship between systemic lupus erythematosus and coronary artery disease: Insights from a meta-analysis and Mendelian randomization

View Full Paper

Ask AI

Bookmark

Authors

PYPing YuanThird Hospital of Changsha LFLi FuThird Hospital of Changsha MGMin GeThird Hospital of Changsha

Discussion

Member takes

Implication

Randomized trial explores the causal link between systemic lupus erythematosus and coronary artery disease, suggesting vigilant monitoring for affected individuals.

Key Points

This research investigates the potential causal relationship between systemic lupus erythematosus (SLE) and coronary artery disease (CAD) using meta-analysis and Mendelian randomization.
Conducted a meta-analysis of 13 cohort studies with 2,517,781 participants.
Employed a two-sample Mendelian randomization using data from genome-wide association studies.
Utilized various statistical approaches including inverse-variance weighted method.
Individuals with SLE show a higher risk of CAD (RR [95% CI] = 2.355 [1.924–2.883]).
Higher risks observed in specific populations: European (RR [95% CI] = 2.028 [1.310–3.138]) and East Asian (RR [95% CI] = 2.628 [1.698–4.067]).
No evidence for a genetically predicted causal relationship between SLE and CAD in MR analysis (P > .05).

Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/6a095c147880e6d24efe21cf https://doi.org/10.1097/md.0000000000048748

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial explores the causal link between systemic lupus erythematosus and coronary artery disease, suggesting vigilant monitoring for affected individuals.

Causal relationship between systemic lupus erythematosus and coronary artery disease: Insights from a meta-analysis and Mendelian randomization

Discussion

Member takes

Implication

Key Points

Cite This Study

Causal relationship between systemic lupus erythematosus and coronary artery disease: Insights from a meta-analysis and Mendelian randomization

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider