Causality analysis of fatty acids, triglycerides and psoriasis based on Mendelian randomization

Studies have shown that an increase in the abundance of triglycerides (TG), oleic acid, and stearic acid can exacerbate the symptoms of psoriasis. Based on this, the present study aimed to employ Mendelian randomization (MR) methods to investigate the causal relationship between fatty acid (FA) and TG levels and the risk of psoriasis. A 2-sample MR analysis was performed using summary statistics from the genome-wide association studies of FA, TG, and psoriasis of European ancestry. Single nucleotide polymorphisms were used as instrumental variables in MR analysis. Inverse variance weighted was used as a primary method to study the causal relationship of FA on psoriasis. Similarly, inverse variance weighted was used to test for the causal effect of TG on psoriasis as well as the causal effect of FA on TG. Finally, sensitivity analysis was used to test the reliability of the MR analysis results. In this study, no significant association was observed between FA and psoriasis, indicating that FA was not a causal factor for psoriasis. TG had a causal relationship with psoriasis, and it was a risk factor for psoriasis. In MR analysis, it was demonstrated that FA did not directly exacerbate psoriasis; TG was a risk factor for psoriasis exacerbation. Our study elucidates the relationship between TG and FAs in psoriasis pathogenesis, thereby refining the understanding of its underlying mechanisms and offering novel theoretical and therapeutic avenues for diagnosis and treatment .