Key result
In isolated rat heart cells, ATP depletion after ischemia-reperfusion is unlikely to limit calcium uptake through Na-Ca exchange if ≥25% of ATP is restored (Km for ATP ≤10% of normal).
Population
Isolated adult rat heart cells
Comparison
ATP depletion followed by reoxygenation with or… vs Control cells or cells with different degrees of…
Design
Preclinical
Authors
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Does not inform clinical reperfusion management; leaves open whether ATP thresholds for Na-Ca exchange apply in vivo.
ATP depletion after ischemia-reperfusion is unlikely to limit calcium uptake through Na-Ca exchange in the whole heart if at least one quarter of ATP is restored.
Haworth et al. (1992) studied Ischemia and reperfusion (experimental). ATP depletion and reoxygenation vs. Control (normal ATP levels) was evaluated on Calcium uptake by Na-Ca exchange. In isolated rat heart cells, ATP depletion after ischemia-reperfusion is unlikely to limit calcium uptake through Na-Ca exchange if ≥25% of ATP is restored (Km for ATP ≤10% of normal).
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