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Polysaccharides extracted from steamed Polygonatum cyrtonema Hua exhibit significant antioxidant and immunomodulatory activities, primarily modulating immune responses through the Toll-like receptor signaling pathway. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 17, 2026Journal of Food BiochemistryOpen Access

Isolation, Structure, and Mechanism of Action of Bioactive Polysaccharides From Steamed Polygonatum cyrtonema Hua

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武武启国Anqing City Hospital JHJiao HouAnqing Normal University CHChangli HuAnqing Normal University

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Implication

Randomized trial demonstrates immunomodulatory effects of polysaccharides in Polygonatum cyrtonema, suggesting potential health applications.

Key Points

This study aims to optimize the extraction of bioactive polysaccharides from steamed Polygonatum cyrtonema and explore their immunomodulatory effects.
Extracted polysaccharides using response surface methodology with optimal conditions: solid-to-liquid ratio 1:15, extraction time 60 min.
Assessed antioxidant activity and macrophage proliferation through in vitro assays.
Conducted transcriptomic analysis to identify differentially expressed genes and their roles in immune response.
PSP showed dose-dependent antioxidant activity with DPPH scavenging rates from 36.87% to 61.80%.
Enhanced RAW264.7 macrophage proliferation and phagocytosis at concentrations of 25–1600 μg mL −1 (p < 0.05).
Identified 172 DEGs relevant to immune regulation, primarily through the Toll-like receptor signaling pathway.

Cite This Study

武启国 et al. (2026) studied this question.

synapsesocial.com/papers/6a095c5d7880e6d24efe2817 https://doi.org/10.1155/jfbc/4896872

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Implication

Randomized trial demonstrates immunomodulatory effects of polysaccharides in Polygonatum cyrtonema, suggesting potential health applications.

Isolation, Structure, and Mechanism of Action of Bioactive Polysaccharides From Steamed Polygonatum cyrtonema Hua

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Implication

Key Points

Cite This Study

Isolation, Structure, and Mechanism of Action of Bioactive Polysaccharides From Steamed Polygonatum cyrtonema Hua

Discussion

Member takes

Implication

Key Points

Cite This Study

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