Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes

Figures

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  Figure 1. Kaplan-Meier Event-Free Survival Curves for Death and MACE According to API and CPO Quartiles Kaplan-Meier event-free survival curves for death (A and B), and MACE (C and D) for API and CPO quartiles, respectively. The median (Q1, Q3) time to death was 8.1 years (4.7, 11.1) and median (Q1, Q3) time to MACE was 4.0 years (0.5, 8.0). API = aortic pulsatility index; CPO = cardiac power output; K-M = Kaplein-Meier; MACE = major adverse cardiovascular event.

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  Central Illustration. Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes Integrated hemodynamic measures API and CPO are associated with future heart failure (HF) hospitalizations across spectrum of cardiovascular disease. The median (Q1, Q3) time to HF hospitalization was 4.5 years (0.9, 8.6). API = aortic pulsatility index; CO = cardiac output; CPO = cardiac power output; DBP = diastolic blood pressure; HF = heart failure; MACE = major adverse cardiovascular event; MAP = mean arterial pressure; PCWP = pulmonary capillary wedge pressure; SBP = systolic blood pressure.

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  Figure 2. Association of Aortic Pulsatility Index and Cardiac Power Output With Clinical Outcomes Association of API (left panel) and CPO (right panel) with clinical outcomes. Multivariable-adjusted HR is referent to quartile 4. Multivariable model adjusted for age, sex, body mass index, hypertension, diabetes mellitus, obstructive sleep apnea, prior myocardial infarction, prior heart failure, and chronic lung disease. HF = heart failure; other abbreviations as in Figure 1.