Why the study?
Are kidney tubule biomarkers associated with cognitive function and decline in community-living older adults?
Cohort (n=2,287)
Yes
Are kidney tubule biomarkers associated with cognitive function and decline in community-living older adults?
Markers of kidney tubule injury and acid/base dysregulation show modest cross-sectional associations with cognitive function in older adults, but do not predict longitudinal cognitive decline.
Association of higher bicarbonate with baseline cognition is hypothesis-generating; does not predict decline and requires prospective validation.
Key Points Higher baseline urinary neutrophil gelatinase-associated lipocalin was associated with worse cognitive scores at baseline. Lower concentrations of baseline serum bicarbonate (higher is better) were associated with lower cognitive scores at baseline. We found no associations with urine markers with longitudinal changes in cognition.
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Miller et al. (2022) conducted a cohort in Cognitive decline (n=2,287). Serum bicarbonate and urine kidney tubule biomarkers was evaluated on Modified Mini Mental State examination (3MSE) score at baseline (β 0.22, 95% CI 0.07 to 0.37, p=0.005).
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