Key result
A measurement error correction developed for metaregression analysis of dietary sodium interventions and blood pressure had a minimal effect on the estimates.
Meta-Analysis
A developed measurement error correction for dietary sodium measures had minimal effect on metaregression estimates of sodium's impact on blood pressure.
Reinforces robustness of sodium-blood pressure metaregression estimates; confirms measurement error correction has negligible influence on results.
In a meta-analysis of randomized trials of the effects of dietary sodium interventions on blood pressure, we found substantial heterogeneity among the studies. We were interested in evaluating whether measurement error, known to be a problem for dietary sodium measures, publication bias, or confounding factors could be responsible for the heterogeneity. A measurement error correction was developed that corrects both the slope and the intercept and takes into account the sample size of each study and the number of measurements taken on an individual. The measurement error correction had a minimal effect on the estimates, although it performed well in simulated data. A smoothed scatter plot was used to assess publication bias. Metaregressions provide a convenient way to jointly assess the effects of several factors, but care must be taken to fit an appropriate model.
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Greenwood et al. (1999) conducted a meta-analysis in Blood pressure. Measurement error correction in metaregression was evaluated on Effect estimates and heterogeneity. A measurement error correction developed for metaregression analysis of dietary sodium interventions and blood pressure had a minimal effect on the estimates.
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