Key result
The L-System CK-MB MtO assay kit, which inhibits mitochondrial creatine kinase, demonstrated a strong correlation (r = 0.996) with conventional kits in patients with obvious acute myocardial infarction while preventing false-positive elevations in patients without AMI.
Why the study?
Does the L-System CK-MB MtO assay kit improve the accuracy of CK-MB measurement by inhibiting MtCK compared to conventional kits in patients with suspected AMI?
Observational (n=338)
No
Does the L-System CK-MB MtO assay kit improve the accuracy of CK-MB measurement by inhibiting MtCK compared to conventional kits in patients with suspected AMI?
Effect estimate: r = 0.996
A new CK-MB assay kit that inhibits mitochondrial creatine kinase activity reduces false-positive CK-MB elevations, potentially improving the diagnostic accuracy for acute myocardial infarction.
May improve AMI diagnostic specificity by curbing false-positive CK-MB; confirms MtCK inhibition benefits in RCT assay validation.
Background: Creatine kinase isoenzyme MB (CK-MB) activity using the immunoinhibition method has been measured in clinical laboratories. However, the presence of mitochondrial CK (MtCK) abnormally increases CK-MB activity when measured using the conventional method, which can lead to misdiagnosis of acute myocardial infarction (AMI). A new CK-MB activity assay kit that can inhibit MtCK activity was recently developed; here, we describe the performance of this kit.
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Masato Maekawa (2012) conducted an observational in Suspected Acute Myocardial Infarction (n=338). L-System CK-MB MtO assay kit vs. Conventional CK-MB assay kit was evaluated on Correlation of CK-MB activity between new and conventional kits in patients with obvious AMI (r = 0.996). The L-System CK-MB MtO assay kit, which inhibits mitochondrial creatine kinase, demonstrated a strong correlation (r = 0.996) with conventional kits in patients with obvious acute myocardial infarction while preventing false-positive elevations in patients without AMI.
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