Key result
Cholesterol reduction lowers CHD incidence by an estimated 2.5% for every 1% reduction in cholesterol (95% CI 1.1-3.9), but must be at least 8-9% to effectively lower total mortality.
Why the study?
Does cholesterol reduction reduce total mortality and coronary heart disease incidence in primary and secondary prevention populations?
Meta-Analysis
Does cholesterol reduction reduce total mortality and coronary heart disease incidence in primary and secondary prevention populations?
Effect estimate: 2.5% reduction per 1% cholesterol reduction (95% CI 1.1-3.9)
Cholesterol reduction effectively lowers CHD incidence, with a 2.5% reduction per 1% cholesterol decrease, but requires at least an 8-9% reduction to lower total mortality.
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Requires ≥8-9% cholesterol reduction to lower mortality; confirms proportional CHD incidence benefit in prevention populations.
Ingar Holme (1990) conducted a meta-analysis in Coronary heart disease. Cholesterol reduction vs. Control was evaluated on Total mortality and coronary heart disease (CHD) incidence (2.5% reduction per 1% cholesterol reduction, 95% CI 1.1-3.9). Cholesterol reduction lowers CHD incidence by an estimated 2.5% for every 1% reduction in cholesterol (95% CI 1.1-3.9), but must be at least 8-9% to effectively lower total mortality.