What question did this study set out to answer?

To resolve the paradox of how CD45 acts as both an essential activator and a suppressor of T cell receptor signaling.

October 22, 2019Science SignalingOpen Access

CD45 functions as a signaling gatekeeper in T cells

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Authors

ACAdam H. CourtneyUniversity of Michigan ASAlexey A. ShvetsPalo Alto Networks (United States)WLWen LuGuangxi University

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Implication

Mechanistic study demonstrates that CD45 balances T cell receptor activation and suppression, indicating a gatekeeping role that filters weak signaling while permitting high-affinity responses.

Key Points

To resolve the paradox of how CD45 acts as both an essential activator and a suppressor of T cell receptor signaling.
Applied chemical and genetic perturbations to titrate the activities of the Csk/CD45 regulatory axis in T cells.
Integrated computational analyses with measurements of Lck activation, TCR ζ-chain phosphorylation, and downstream signaling across low- and high-affinity antigens.
Acute inhibition of Csk demonstrated that CD45 directly suppresses ζ-chain phosphorylation while maintaining a regulatable pool of active Lck.
CD45 selectively suppressed antigen-independent and low-affinity antigen signaling without impairing signals induced by high-affinity antigens.

Cite This Study

Courtney et al. (2019) studied this question.

synapsesocial.com/papers/6a09798d16dfdfe7ed341ff7 https://doi.org/10.1126/scisignal.aaw8151

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Implication

Mechanistic study demonstrates that CD45 balances T cell receptor activation and suppression, indicating a gatekeeping role that filters weak signaling while permitting high-affinity responses.

CD45 functions as a signaling gatekeeper in T cells

Discussion

Member takes

Implication

Key Points

Cite This Study

CD45 functions as a signaling gatekeeper in T cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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