Key result
Single-lead V5 ECG neural network detects dHCM with ~0.95 AUC, matching eight-lead performance.
Why the study?
The study sought to develop an artificial intelligence model to detect the dilated phase of hypertrophic cardiomyopathy on digital ECG and evaluate its performance across multiple-lead, double-lead, or single-lead ECGs.
Does a convolutional neural network applied to single-lead ECG detect the dilated phase of hypertrophic cardiomyopathy as accurately as an eight-lead ECG model?
Cohort (n=17,378)
No
Does a convolutional neural network applied to single-lead ECG detect the dilated phase of hypertrophic cardiomyopathy as accurately as an eight-lead ECG model?
An AI-derived CNN model applied to a single V5 lead ECG can accurately detect the dilated phase of hypertrophic cardiomyopathy, performing comparably to an eight-lead ECG model.
Background: This study sought to develop an artificial intelligence-derived model to detect the dilated phase of hypertrophic cardiomyopathy (dHCM) on digital electrocardiography (ECG) and to evaluate the performance of the model applied to multiple-lead or single-lead ECG. Methods: This is a retrospective analysis using a single-center prospective cohort study (Shinken Database 2010-2017, n = 19,170). After excluding those without a normal P wave on index ECG (n = 1,831) and adding dHCM patients registered before 2009 (n = 39), 17,378 digital ECGs were used. Totally 54 dHCM patients were identified of which 11 diagnosed at baseline, 4 developed during the time course, and 39 registered before 2009. The performance of the convolutional neural network (CNN) model for detecting dHCM was evaluated using eight-lead (I, II, and V1-6), single-lead, and double-lead (I, II) ECGs with the five-fold cross validation method. Results: The area under the curve (AUC) of the CNN model to detect dHCM (n = 54) with eight-lead ECG was 0.929 (standard deviation [SD]: 0.025) and the odds ratio was 38.64 (SD 9.10). Among the single-lead and double-lead ECGs, the AUC was highest with the single lead of V5 (0.953 [SD: 0.038]), with an odds ratio of 58.89 (SD:68.56). Conclusion: Compared with the performance of eight-lead ECG, the most similar performance was achieved with the model with a single V5 lead, suggesting that this single-lead ECG can be an alternative to eight-lead ECG for the screening of dHCM.
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Hirota et al. (2023) conducted a cohort in Dilated phase of hypertrophic cardiomyopathy (dHCM) (n=17,378). Convolutional neural network (CNN) model applied to single-lead (V5) ECG vs. CNN model applied to eight-lead ECG was evaluated on Detection of dHCM (AUC) (OR 58.89). A convolutional neural network applied to a single V5 lead ECG detected the dilated phase of hypertrophic cardiomyopathy with an AUC of 0.953, performing similarly to an eight-lead ECG (AUC 0.929).
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