Key result
Adipokines show potential as biomarkers and therapeutic targets for CV complications in T2D.
Why the study?
Patients with type 2 diabetes are prone to cardiovascular complications, and a disturbed balance between pro-inflammatory and protective adipokines promotes the pathogenesis of these complications.
Adipokines show potential as biomarkers for diagnosis, prognosis, and follow-up of cardiovascular complications in type 2 diabetes, as well as targets for new therapeutic approaches.
Adipokines remain investigational for cardiovascular risk assessment in type 2 diabetes; leaves open prospective trials to validate clinical utility.
Over the past decades, there has been a major increase in type 2 diabetes (T2D) prevalence in most regions of the world. Diabetic patients are more prone to cardiovascular complications. Accumulating evidence suggests that adipose tissue is not simply an energy storage tissue but it also functions as a secretory tissue producing a variety of bioactive substances, also referred to as adipokines. The balance between pro-inflammatory adipokines and protective adipokines is disturbed in type 2 diabetes, this can be regarded as adipose tissue dysfunction which partly promote the pathogenesis of diabetes complications. In this review, we not only discuss the favorable adipokines like adiponectin, omentin, C1q tumor necrosis factor-related proteins, but also unfavorable ones like resisitin and visfatin, in the aim of finding potential biomarkers recommended for the clinical use in the diagnosis, prognosis and follow up of patients with T2D at high risk of developing cardiovascular diseases as well as leading to new therapeutic approaches.
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Liang et al. (2019) conducted a review in Type 2 diabetes mellitus with vascular complications. Adipokines (as biomarkers and therapeutic agents) was evaluated. Adipokines, including favorable ones like adiponectin and unfavorable ones like resistin, have potential as biomarkers and therapeutic targets for cardiovascular complications in type 2 diabetes.
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