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March 13, 2015PLoS ONEOpen Access

Circulating Level of CTRP1 in Patients with Nonalcoholic Fatty Liver Disease (NAFLD): Is It through Insulin Resistance?

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Key result

Higher CTRP1 strongly correlates with NAFLD, T2DM, and insulin resistance.

  • P<0.0001
  • n=87

Why the study?

Does plasma CTRP1 level correlate with insulin resistance and liver stiffness in patients with NAFLD and T2DM?

Population

87 men aged 43-72 years, including 22 with NAFLD, 22 with T2DM, 22 with NAFLD+T2DM, and 21 healthy subjects…

Comparison

Measurement of plasma CTRP1 concentration vs Healthy subjects (n=21)

Design

Cross-sectional

Authors

PSParisa ShabaniHKH Naeimi KhalediMBMaani Beigy

Discussion

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Overview

CTRP1 may mark insulin resistance severity in NAFLD/T2DM; leaves open biomarker utility pending prospective validation.

Study Design

Type

Observational (n=87)

Multicenter

No

Structured PICO

Does plasma CTRP1 level correlate with insulin resistance and liver stiffness in patients with NAFLD and T2DM?

P
Population
87 men aged 43-72 years, including 22 with NAFLD, 22 with T2DM, 22 with NAFLD+T2DM, and 21 healthy subjects. Excluded: excessive alcohol consumption, viral hepatitis, autoimmune liver disease, hemochromatosis, Wilson's disease, renal disease, type 1 diabetes mellitus, and use of steatosis-inducing medications.
I
Intervention
Measurement of plasma CTRP1 (complement-C1q TNF-related protein 1) concentration
C
Comparator
Healthy subjects (n=21)
O
Outcome
Plasma concentration of CTRP1 and its correlation with metabolic and hepatic parameters (FBG, HOMA-IR, BMI, ALT, gamma-GT, and liver stiffness)surrogate

Main Result

p-value: p=<0.0001

Limitations

  • Could not investigate other adipokines as possible pathogenic pathways involved with CTRP1 effects
  • Small sample size
  • Cross-sectional design limits the ability to establish causality

Cite This Study

Shabani et al. (2015) conducted an observational in Nonalcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Mellitus (T2DM) (n=87). Plasma CTRP1 levels vs. Healthy subjects was evaluated on Plasma concentration of CTRP1 (p=<0.0001). Plasma concentrations of CTRP1 were significantly higher in patients with NAFLD, T2DM, and NAFLD+T2DM compared to healthy subjects and strongly correlated with insulin resistance.

synapsesocial.com/papers/6a09bb2516dfdfe7ed34545ahttps://doi.org/10.1371/journal.pone.0118650
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical approaches to non-alcoholic fatty liver disease2014 · 134 citations
  2. 2Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis2007 · 234 citations
  3. 3Cytokines in the Pathogenesis of Fatty Liver and Disease Progression to Steatohepatitis: Implications for Treatment2008 · 206 citations
  4. 4Adipokines and cytokines in non‐alcoholic fatty liver disease2007 · 430 citations