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March 1, 1992Proceedings of the National Academy of SciencesOpen Access

Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine.

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Authors

PKPaul KellamAugusta UniversityCBCharles A. BoucherBoston UniversityBLBrendan LarderStichting HIV Monitoring

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Kellam et al. (1992) studied this question.

synapsesocial.com/papers/6a09bfadb0d552aa8b45de35https://doi.org/10.1073/pnas.89.5.1934
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Also Consider

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  1. 1Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay1990 · 199 citations
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  4. 4Detection of human immunodeficiency virus type 1 clinical isolates with reduced sensitivity to zidovudine and dideoxyinosine by RNA.RNA hybridization.1991 · 71 citations
  5. 5Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template1984 · 906 citations